2-4号外显子前后各有loxP位点,下游的FRT引导的抗氨苄青霉素抗性基因(cassette with PGK-neo)在loxP位点内插入。通过Cre介导的重组,选择性 cassette 被移除,使得2-4号外显子被去除了(来源:J:306874)
Basic Information
129S6/SvEvTac and C57BL/6J
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count