通过小鼠胚胎干细胞中的标准同源重组,导向载体将iCre-IRES-Flag-EGFP-pgk-gb2neo-polyA片段插入Drd2基因的起始翻译位点,且序列保持同源框内。RT-PCR结果显示,纯合子小鼠中Drd2 mRNA水平极低,这是一项无功能的等位基因(J:301337)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6N
Targeted
插入
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1
1
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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