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中文
通过在ES细胞中通过同源重组靶向，将包含起始密码子的exon(ENSMUSE00001275521)的序列用loxP序列包裹，后面跟着由Frt序列包裹的Pgk-neo cassette。随后，通过与Rosa-Flp小鼠杂交，移除了Pgk-neo cassette。接着，这些小鼠与表达Cre的生殖细胞特异性突变的鼠交配，以删除含起始密码子的exon。 Western blot分析证实了纯合突变雌性新生卵巢中蛋白表达的缺失。这是一项无功能的突变基因。(来源：J:282136)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
