通过在ES细胞中通过同源重组靶向,将包含起始密码子的exon 3(ENSMUSE00001275521)用loxP序列包裹,后面跟着由Frt序列包裹的Pgk-neo cassette。随后通过与Rosa-Flp小鼠杂交移除Pgk-neo cassette(J:282136)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6NCrlj x CBA/JNCrlj)F1
Targeted
插入
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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