CRISPR/cas9导向的基因组编辑用于在第18外显子插入血凝素(HA)标签和终止密码子,位于细胞质区域。 Western blot结果显示,这种变异导致大脑、心脏、肺、肝脏和脾脏中蛋白质水平降低。(来源:J:306272)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
B6(Cg)-Tyrc-2J/J
Endonuclease-mediated
插入
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1
2
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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