Meis2^tm1.1Mtor

The targeting vector introduced loxP sites flanking mouse Meis2 exon 3 and FRT-PGK-gb2-neo-FRT cassette. The targeting vector was electroporated into ES cells. Chimeras were generated by ES cell aggregation. The neomycin resistance cassette was eliminated by crossing with a Flpe deleted mouse. Deletion of this exon results in a premature stop codon, which eliminates all functional domains of the Meis2 protein. (J:301894)