CRISPR技术产生的点突变是在第14位由丝氨酸替换为精氨酸(由C变G),这被称为S14R的氨基酸替换。一个无义突变(由C变T)产生了一个Aat I的限制性酶切位点,以方便遗传型鉴定。(来源:J:291454)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6J
Endonuclease-mediated
核苷酸替换
--
1
2
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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