Exon 3通过将编码两个gRNAs和Fok1-dCas9融合基因的质粒通过微注射方式注入到受精卵的极体中,利用了CRISPR/Cas9技术来靶向。在创始系11中,这导致了19个bp的缺失,以及一个点突变(或者20bp的缺失和1bp的插入或重复)(来源:J:273448)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Applicable
Endonuclease-mediated
Intragenic deletion, Single point
--
1
--
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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