在小鼠染色体11上,一个157千碱基对的缺失被一个来自人类染色体17(HSA17)的同源190千碱基对区域替换,这个区域不包括Crhr1到Kansl1。在这个区域中,鼠的Sppl2c(信号肽酶2C)和Mapt(微管相关蛋白tau)基因被替换成了人类的SPPL2C和MAPT(H1亚型基因)。通过暂时的Cre表达,一个含loxN标记的诺卡因抗性基因 cassette被去除了。(来源:J:101977)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6NTac
Targeted
Insertion, Intergenic deletion
--
2
--
--

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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