Tc(HSA17*N279K)1Mdk

A 157 kb deletion on mouse chromosome 11 stretching from, but not including, Crhr1 to Kansl1 is replaced by a syntenic 190 kb region from human chromosome 17 (HSA17). The mouse Sppl2c (signal peptide peptidase 2C) and Mapt (microtubule-associated protein tau) genes are replaced by human SPPL2C and MAPT (H1 haplotype) genes. The human MAPT gene was modified to include the N279K (asparaginine to lysine) mutation identified in FTD patients. A loxN-flanked neomycin resistance cassette that was removed by transient cre expression. (J:101977)