CRISPR/Cas9技术(通过sgRNA5'-CACCAACCGATCAGACTGTG-3'引入)导致了AC变为GA,氨基酸1305位置的arginine替换为histidine(R1305H),这与人类精神分裂症患者中发现的R1346H变异对应。(引用:J:302192)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count