CRISPR/Cas9技术(通过sgRNA5'-CACCAACCGATCAGACTGTG-3'引入)导致了AC变为GA,氨基酸1305位置的arginine替换为histidine(R1305H),这与人类精神分裂症患者中发现的R1346H变异对应。(引用:J:302192)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Endonuclease-mediated
核苷酸替换
--
1
2
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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