通过BAC重组技术,大约3兆碱基对的鼠基因座,包括Vh、Dh和Jh基因片段,被替换为约940千碱基的人类连续序列,其中包含相应的人类基因片段。替换的近端接点位于J段下游约200个碱基处,远端接点位于人类基因最上游的V段上游几百个碱基,且距离J558.55的最上游约9千碱基下游。(J:208619)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(129S6/SvEvTac x C57BL/6NTac)F1
Targeted
插入,基因内删除
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--
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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