将含有loxP位点和基因第3外显子周围序列的靶向寡核苷酸,以及Cas9/gRNA的核糖核酸颗粒,一起注入到囊胚中。通过Cre介导的重组,去除了第3外显子(来源:J:296556)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6J
Endonuclease-mediated
插入,基因内删除
--
1
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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