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中文
包含6-9号外显子的1.6kb片段被替换为一个核定位信号、LacZ报告基因、Engrailed-2的内含子和剪接接受体位点(En-2/SA)，以及一个内部核糖体进入位点后跟着一个由loxP标记的磷酸甘油酸激酶-neomycin抗性基因。通过Cre介导的重组，loxP标记的PGK-neomycin抗性基因在生殖细胞中被移除。使用单克隆抗TMC8抗体的 Western blot 分析证实，纯合突变小鼠胸腺细胞的提取物中没有蛋白表达。(来源：J:300461)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
