这个转基因构建包含了一段经过密码子优化的flp重组酶,后面跟着由murine heat shock response element(Hspa1b,之前称为Hsp70-1)启动子/增强子序列驱动的bGHpolyA序列。随后,A4创始系被选择以保证持续表达。初步的全基因组测序分析表明,转座子插入了18号染色体的Tcerg基因座的内含子区域,并且与周围区域的序列方向相反。(来源:J:303219)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6J
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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