这个靶向载体设计用于替换小鼠X染色体上一段66kb(65,812bp),从collectrin(Cltrn)氨基酸转运调节基因起,但不包括BMX非受体酪氨酸激酶(Bmx)基因,这段区域与人类X染色体的同源序列是71kb(70,987bp)。在人类ACE2和小鼠Bmx基因的接合点,插入了一个由loxN标记的诺卡因抗性(neo)基因片段。短暂的Cre介导的重组移除了含有的floxed neo cassette。(来源:J:101977)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NTac
Targeted
插入
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1
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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