Abi3^em1Aduci

CRISPR/cas9 genome editing is used to create an TCT to TTC missense mutation resulting in a serine to phenylalanine change (S212F). This mutation (SNP rs616338) is homologous to the human S209F SNP which has been shown to correlate with increased risk of sporadic Alzheimer's disease. One silent DNA mutation was also introduced. (J:101977)