使用BAC RP23-122N18,我们替换掉了第一个编码外显子,替换成包含Fast Fluorescent Timer(FT)基因、poly(A)信号序列和由loxP序列 flank 的诺卡因抗性基因 cassette。随后通过Cre介导的重组,删除了neo cassette。FT基因是mCherry(M18V E34K K69R L84W S149T A224S)的突变版本。(来源:J:264610)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6
Targeted
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1
1
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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