这个靶向构建旨在删除基因12中的4个碱基(TCTT),这与精神类神经疾病如精神分裂症患者中发现的缺失相似。下游插入了由loxP序列引导的诺卡因(neo)抗性基因座。通过小鼠的生殖细胞,Cre介导的重组移除了neo基因座。(来源:J:304928)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6
Targeted
基因内删除
--
1
2
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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