使用sgRNAs和ssODN模板,通过CRISPR/Cas9技术,该基因被修改,使其同源区段类似于人类的C4A基因:内源性密码子序列PCPVIH被替换为PCPVLD(突变位点为p.I1120_H1121delLDins,参考文献:J:301308)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6J
Endonuclease-mediated
核苷酸替换
--
1
7
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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