Ppp2r2b基因的N端24个氨基酸(第1外显子)被替换为lacZ的编码序列,周围是两对loxP位点和一个polyadenylation信号,以终止转录。通过和一个Cre敲除小鼠杂交,成功去除了neo基因座。这个等位基因是一个无功能的突变体。蛋白产物缺失通过 Western blotting 在总前脑提取的PP2A全酶中得到了确认。(来源:J:290154)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
插入,基因内删除
--
1
1
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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