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引导RNA(GATGAGCTGCAACTCAAAGC)被设计用于产生一个AAA替换为AGG的错义突变，导致第537位的赖氨酸(K537R)变为arginine。K537R突变与人类的K542R单核苷酸变异位点（SNP）同源，已知与散发性阿尔茨海默病风险增加有关。此外，还引入了一个silent DNA突变。(来源：J:101977)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
