Cyp19a1^tm1.2Hzh

A loxP site was inserted upstream of the promotor and an FRT-flanked neomycin resistance cassette and a second loxP site were inserted in intron 2. The loxP-flanked region encompasses 4.9-kb of the promoter region, 0.6-kb of the gonad-specific first exon (PII), exon 2, and part of intron 2. Flp-mediated recombination removed the neomycin selection cassette and cre-mediated recombination deleted the floxed region (promotor, exon 1 and exon 2). (J:298580)