FLPe-mediated excision of the parental Aicdatm1a(EUCOMM)Hmgu allele resulted in the removal of the lacZ reporter sequence and promoter-driven neomycin selection cassette leaving exon 3 flanked by loxP sites. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:297378)