通过FLPe介导的父本Aicdatm1a(EUCOMM)Hmgu等位基因的切除,去除了lacZ报告序列和由启动子驱动的诺卡因选择标记基因,剩下的是exon 3被loxP序列环绕。有关这种IKMC等位基因以及其他类似靶向策略的更多信息,可访问http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml(来源:J:297378)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count