Exon 1通过两个TALENs(序列GCACCATGCCTGCCTG和AGTAGGAGGCCAGCGGC)进行了靶向,产生了17个bp的缺失(序列TCGCCTCTGCTTGCTGG)。qRT-PCR和 Western blot的结果表明,这个等位基因没有检测到mRNA和蛋白质的表达。(来源:J:293623)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count