在exon 8的上游插入了loxP序列,然后在exon 8的下游插入了一个由FRT序列引导的neo cassette,该 cassette带有3'的loxP位点。通过Flp介导的重组去除了选择性 cassette,随后通过Cre介导的重组删除了exon 8。(来源:J:104881)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
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1
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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