在chr8:96599337-96612356位置,插入了loxP引导的诺姆西林选择座,包含了5到13号外显子。通过Regeneron的VelociMouse平台,产生了实验鼠。随后,通过Cre介导的重组,去除了含有的floxed neo cassette。(来源:J:296033)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count