通过定点突变,将serine 273的密码子替换为alanine(TCA变为GCA),用以(p.S273A)阻止编码肽中该位置的磷酸化。随后通过Cre介导的重组,移除了内含一个loxP序列标记的诺卡因抗性基因元件。这段内容出自文献(J:296627)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6
Targeted
单点
--
1
10
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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