这个靶向构建旨在用一个含LoxP切割位点的诺姆基质 cassette 替换exon 1。exon 1 包含DM域,一种类似锌指的DNA结合位点,以及转录起始点。通过Cre介导的重组,去除了含floxed neo的 cassette。(来源:J:254118)
Basic Information
129S1/Sv-Oca2+ Tyr+ Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count