这个靶向构建旨在用一个含LoxP切割位点的诺姆基质 cassette 替换exon 1。exon 1 包含DM域,一种类似锌指的DNA结合位点,以及转录起始点。通过Cre介导的重组,去除了含floxed neo的 cassette。(来源:J:254118)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
基因间区删除
--
1
1
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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