这个靶向构建设计用于将exon 2替换为插入了人类ACE2基因组的同框的人工cDNA。此外,ACE2基因上游放置了一个loxP位点,随后是含FRT标记的诺卡因抗性(neo)片段,而在cDNA下游则放置了另一个loxP位点。通过Flp介导的重组,FRT标记的neo片段被去除了。(来源:J:296356)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
插入,基因内删除
--
1
--
9

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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