从结核杆菌(M. tuberculosis)来源的分泌蛋白中,提取了TCRα链可变区(VJ)和β链可变区(VDJ)的cDNA。细胞克隆7,针对ESAT-63-15肽有特异性的CD4+ T细胞,其表达的TCR链为Vβ10b-Dbeta1.1-Jbeta2.4和Valpha11.2-Jalpha27。完整的TCRα和β链被完整克隆到使用了人类CD2启动子驱动在T细胞中表达的VA hCD2 cassette载体中。(参考文献:J:141135)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6J
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1
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4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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