在基因的起始翻译位点插入了EGFP-IRES-creERT2元件,同时伴随一个含loxP切割位点的诺卡因基因座。之后,通过与一个含cre删除突变体的交叉,体内实现了诺卡因基因的剔除。EGFP的表达由内源性启动子驱动。Cre的表达则在施用Tamoxifen处理后,出现在Smoc2表达的细胞中。(来源:J:186432)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入
--
1
1
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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