Exon 3被替换为一个带有核苷酸替换的,导致第114位的Arginine被Aspartic acid替换(R114D)。通过Flp介导的重组,去除了插入到内含子5的筛选元件,以及内含子9的puromycin cassette。剩下的6到9号外显子保持了可翻转状态。(来源:J:288980)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NTac
Targeted
核苷酸替换
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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