Exon 2通过CRISPR/Cas9技术用sgRNAs进行了靶向。建立了4个非同源插入/缺失插入的转基因小鼠品系,分别命名为A15(替换为TTTAG的缺失-AGCT的插入),A20(AGTCTC的缺失-T插入),AG1(插入A),和AG7(插入A)。来源:(J:295190)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6
Endonuclease-mediated
插入,基因内删除
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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