Exon 2通过CRISPR/Cas9技术用sgRNAs进行了靶向。建立了4个非同源插入/缺失插入的转基因小鼠品系,分别命名为A15(替换为TTTAG的缺失-AGCT的插入),A20(AGTCTC的缺失-T插入),AG1(插入A),和AG7(插入A)。来源:(J:295190)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count