一种FRT-flankedPGK-neo选择座位于内源基因的polyadenylation信号下游,loxP序列位于起始密码子(ATG)上游46bp处,以及neo座序的下游。3'端的loxP位点后面跟着Mafa的突变形式(Mafa-4A),它能阻止GSK3对蛋白质的磷酸化(来源:J:325444)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
Insertion, Nucleotide substitutions
--
1
1
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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