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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Mafa
tm2Eyc
Alias:
Mafa
tm2(4A)Eyc
Mafa
flox4a
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基础信息
表型特征
文献报道
一种FRT-flankedPGK-neo选择座位于内源基因的polyadenylation信号下游,loxP序列位于起始密码子(ATG)上游46bp处,以及neo座序的下游。3'端的loxP位点后面跟着Mafa的突变形式(Mafa-4A),它能阻止GSK3对蛋白质的磷酸化(来源:J:325444)。
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
6459714
129S2/SvPas
Targeted
Insertion, Nucleotide substitutions
--
1
1
1
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
No Data Found!
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