通过Cre介导的父本Serinc5tm1a(KOMP)Wtsi基因座的去除,去除了由启动子驱动的诺卡因选择标记片段,同时保留了插入的lacZ报告序列。同源纯合子的RT-qPCR结果显示mRNA转录水平显著降低。更多关于这种IKMC等位基因以及其它靶向策略的信息,可访问http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml(来源:J:291232)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6N
Targeted
插入,基因内删除
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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