在内含子1中插入了LoxP位点,随后在内含子2中加入了第二个LoxP位点和FRT序列,伴随着诺卡因抗性基因座。通过Cre介导的删除(Tek-cre转基因),实验确认了第2外显子的缺失,以及该等位基因的表达缺失。(来源:J:294294)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6
Targeted
基因内删除
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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