在第3个内含子插入了loxP位点和FRT位点,伴随着一个诺卡因抗性基因座,然后在第6个内含子插入了另一个loxP位点。通过后续的Flp介导重组,去除了诺卡因抗性基因座。通过Cre介导的重组,删除了4-6号外显子。免疫组化结果显示,这个等位基因不表达肽。(来源:J:281205)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129
Targeted
插入,基因内删除
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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