在exon 5的上游插入了loxP位点和FRT引导的诺卡因抗性基因,而在exon 6的下游则插入了F3标记的puromycin抗性基因和另一个loxP位点。通过Flp介导的重组,选择性载体被去除,使得exons 5-6区域被标记为可翻转。(来源:J:269067)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count