Exons 3和4被替换成一个通用对接座 cassette。这个cassette包含一个splice接受器-βgeo-lacZ序列、一个loxP位点,接着是deltaTK和neomycin,由人类β-actin启动子控制,第二个loxP位点,一个PhiC31 attP位点,以及一个只有在PhiC31在attP位点插入启动子时才活跃的puromycin序列。(来源:J:270051, J:290434)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6
Targeted
插入,基因内删除
--
1
--
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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