在第二个外显子的起始密码子(AUG)被替换为终止密码子(UAG),并且在驱动子2(P2)可能的转录起始点大约200bp上游区域被移除了。这个等位基因仍能从驱动子1(P1)获取表达,但不能从P2。通过Cre介导的重组,蜂巢式新霉素抗性基因座被去除了。(来源:J:245723)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129 x C57BL/6)F1
Targeted
Insertion, Intragenic deletion, Nucleotide substitutions
--
1
8
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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