Picalm^em1Aduci

CRISPR/Cas9 genome editing is used to create a CAT to AGA mutation, resulting in a histidine to arginine change at amino acid 465 (H465R) of the gene. This mutation H465R is homologous to the human SNP, H458R, shown to correlate with increased risk of Alzheimer's disease. (J:101977)