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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Ryr1
em2Jjd
Alias:
Ryr1
Indel
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基础信息
表型特征
文献报道
CRISPR/Cas9基因编辑引入了chr7:29013738到29013752位置的16bp缺失,这是在基因96的外显子区域。测序N1后代后发现,修复模板没有整合到这个等位基因中,这是由于非同源末端连接修复造成了双链断裂。来源:J:275500
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
6437883
C57BL/6NCrl
Endonuclease-mediated
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1
26
1
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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