CRISPR/Cas9基因编辑引入了chr7:29013738到29013752位置的16bp缺失,这是在基因96的外显子区域。测序N1后代后发现,修复模板没有整合到这个等位基因中,这是由于非同源末端连接修复造成了双链断裂。来源:J:275500

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NCrl
Endonuclease-mediated
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1
26
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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