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中文
将人类的R684H、F681Y、G676R和KM670/671NL（瑞典变体）基因突变引入第16号外显子，通过靶向载体实现。在第16个内含子中，放置了反向转录方向的FRT引导的PGK-neomycin cassette和F3引导的PGK-hygromycin cassette。同时，E693G（Artic）和T714I（Austrian）的突变被引入第17号外显子。Flpe介导的重组去除了FRT引导的neomycin和hygromycin cassette。来源：(J:299724)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
