Mir34b和Mir34c所在的区域由loxP座标记。远端的loxP座插入在Mir34c序列大约400bp下游的非保守区域。一个阳性选择座(NeoR)由FRT重组座环绕,并与近端的loxP座一同,插入在Mir34b序列上游约800bp的非保守区域。在通过Flp介导去除选择标记后,获得了条件性等位基因。随后,Cre介导的重组会移除微小RNA簇。(来源:J:147112)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6NTac
Targeted
插入,基因内删除
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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