Mir449a、Mir449b和Mir449c所在的簇被LoxP位点包夹。Mir449簇位于预测的Cdc20b小鼠基因(ENSMUSG00000078926)内第2个内含子中。Mir449c位于Cdc20b基因预测的第2个外显子下游206bp的位置。靠近的LoxP位点被插入到了这206bp内。重组移除了选择性元件和微小RNA簇。(来源:J:147112)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6NTac
Targeted
插入,基因内删除
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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