这个转基因构建包含了5个8.5kb的mouse CaM-kinase II alpha链(mCamk2a)启动子片段,一个850bp的人类β-珠蛋白内含子2的DNA片段,以及2247bp的人类PLA2G4A cDNA的ORF(GenBank Acc# NM_024420),在3'端跟着221bp的SV40poly A序列,所有这些都插入在pGL3载体的背景下。在mCamk2a启动子上游,增加了一个共识的KOZAK序列。(来源:J:147112)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6
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插入
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1
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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