Erc2^em1Adiuj

Plasmids encoding single guide RNAs were designed to introduce the N542S point mutation (AAT>AGT), the V543V silent mutation (GTT>GTC) and L544L silent mutation (CTT>CTC) into exon 7. The N542S mutation models a missense variant (rs12488237 SNP) that is associated with late-onset Alzheimer's disease risk. (J:101977)