在包含Cyp2ctm1Wolf插入的人源序列,对应人类CYP2C9基因1到4号外显子、4号内含子以及5到9号外显子,连接到一个由8.5-10.4kb BamHI/NheI增强子和0.3kb小鼠血清albumin上游调控区的启动子片段的ES细胞中,Cre重组发生了。通过Flp介导的重组,选择性载体被移除了。(来源:J:241121)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6NTac
Targeted
Deletion, Insertion
--
1
--
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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