在基因的上游插入了一个loxP位点,随后是含氨苄青霉素抗性基因座的FRT序列,再接着是一个下游的loxP位点。通过后续的Flp介导重组,去除了neo cassette,留下了一个条件性可操作的等位基因,其中基因被标记为敲除(J:266583)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129X1/SvJ
Targeted
插入
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4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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